How do investors gauge whether a company is one from a pool of thousands worth their resources? KPCB partner Beth Seidenberg shares her firm's five measures for financial fortitude. In this clip, she outlines leadership, and how this is the most important talisman of a growing enterprise's success. In addition, she discusses the importance of large, fast-growing, under-served markets, and KPCB's willingness to take risk with new technologies. Reasonable financing structures and a sense of market urgency are also key indicators; being the first and being the best matters. Founders who are missionaries, not mercenaries, nearly always seal the deal. 

Amyris Biotechnologies CEO John Melo explains his company's endeavors in the sustainable sciences; working both to fight disease and to create renewable energies. Melo also reflects upon his personal career path, from immigrant, to start-up, to Big Oil - and back to start-up again.