David Heineimeier Hansson, the creator of Ruby on Rails and partner at 37signals in Chicago, says that planning is guessing, and for a start-up, the focus must be on today and not on tomorrow. He argues that constraints--fiscal, temporal, or otherwise--drive innovation and effective problem-solving. The most important thing, Hansson believes, is to make a dent in the universe with your company. 

Guy Kawasaki, founder and Managing Director of Garage Technology Ventures, believes that those companies who set out to make a positive change in the world are the companies that will ultimately be the most successful. He gives examples of the best way to make meaning: increase quality of life, right a wrong, and prevent the end of something good. 

Serial entrepreneur Marc Andreessen offers the Stanford audience a rare opportunity to pose open questions. Topics addressed include everything from the state of VC and the stock market, to Facebook's market dominance, to the rebirth of consumer electronics. In addition, Andreessen offers ground rules for the start-up, including tips on attracting top talent.  

Stanford Technology Ventures Program's Executive Director Tina Seelig shares rich insights in creative thinking and the entrepreneurial mindset. Her talk, based on her 2009 book, What I Wish I Knew When I Was 20, cites numerous classroom successes of applied problem-solving and the lessons of failure. 

Jerry Kaplan, serial entrepreneur, executive, technical innovator, and author, elaborates on the five biggest mistakes that entrepreneurs make: 1) Having unclear goals and an unclear mission. 2) Trying to prove that they are smart. 3) Greed - doing it for money. 4) Hiring people that they like rather than people that they need. 5) Not knowing when to let go.