In this clip, Square and Twitter Co-Founder Jack Dorsey shares how Twitter came into existence, while he was working at Odeo, a consumer podcasting company. Dorsey joined Odeo to gain a greater understanding of the consumer Internet market, but eventually learned that few people at the company, including him, were interested in podcasting. Dorsey says the Twitter project began at Odeo, when at the company's urging for new ideas, he suggested the concept that would become Twitter. 

UCSF Chancellor Susan Desmond-Hellmann shares a story to illustrate how innovation occurs in the field of biotechnology. She describes the development of an innovative cancer drug at Genentech, even in the face of great skepticism, and the team effort it took to gain regulatory approval. 

Netscape Co-founder (and current serial entrepreneur) Marc Andreessen speaks candidly about Netscape's necessary pivots when it was threatened by Microsoft's Internet Explorer in the late 1990's. He recalls that making the browser free, as well as focusing on the website and business applications, propelled the company's success in a turbulent market.