Zymergen’s Joshua Hoffman talks about the importance of learning how to reason from first principles, and not basing your actions simply on what has worked before. By going “up a layer of abstraction” and thinking theoretically, you can rise above a problem and see your way out of it. He says this approach should be supplemented by diving deep into your data.
Related

John Felts,
Cruz Foam
Engineering Green Materials [Entire Talk]
To scale a technology, engineers need to think beyond the technology itself.
Video
53 minutes
John Felts,
Cruz Foam
Engineering Green Materials [Entire Talk]
To scale a technology, engineers need to think beyond the technology itself.

Kristen Fortney,
BioAge Labs
Derisking Biotech [Entire Talk]
Biotech offers huge rewards for founders who approach risk strategically.
Video
53 minutes
Kristen Fortney,
BioAge Labs
Derisking Biotech [Entire Talk]
Biotech offers huge rewards for founders who approach risk strategically.

Alfred Lin,
Sequoia Capital
Developing a Founder’s Mindset [Entire Talk]
Strategic founders pursue calculated risks and are willing to evolve.
Video
54 minutes
Alfred Lin,
Sequoia Capital
Developing a Founder’s Mindset [Entire Talk]
Strategic founders pursue calculated risks and are willing to evolve.